Eliseo Guallar
Eliseo Guallar
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Chair and Professor of the Department of Epidemiology
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Professional overview
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Dr. Guallar is an epidemiologist whose research is focused on the study of cardiovascular disease epidemiology and prevention, with an emphasis on evaluating the role of environmental and nutritional exposures in the development of cardiovascular disease. This research has made critically important and novel contributions to our understanding of risk factors for chronic disease both in the US and globally. He has published seminal articles and is a leading figure in an emerging field highlighting the risks of exposure to levels of metals previously considered safe for cardiovascular health. In addition to his work in toxic metals, Dr. Guallar has made important contributions to understanding the effects of certain micronutrients and vitamin supplements on cardiovascular disease risk and outcomes. Publications in this area were influential in changing consumer habits and attitudes towards these products. Much of this research has been funded by the National Institutes of Health, the Agency for Healthcare Research and Quality, the American Heart Association, the CDC, and other funders.
Dr. Guallar was the founding director of the Center for Clinical Epidemiology at the Samsung Medical Center and a lead investigator of the Kangbuk Samsung Cohort Study at the Kangbuk Samsung Hospital since its inception in 2010. Dr. Guallar has published over 500 research papers in peer-reviewed journals. He is also a Deputy Editor for Methods at the Annals of Internal Medicine and a past member and Chair of the Cancer, Heart, and Sleep Study Section at the National Institutes of Health.
Prior to teaching at NYU, Dr. Guallar was a Professor of Epidemiology and Medicine at the Johns Hopkins University Bloomberg School of Public Health and a core faculty member of the Welch Center for Prevention, Epidemiology, and Clinical Research at Johns Hopkins. In the Department of Epidemiology, Dr. Guallar was the Director of the Environmental and Occupational Area of Concentration and the Co-Director of the PhD Program. Dr. Guallar was also an adjunct Professor at the Department of Clinical Research Design and Evaluation of the Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, in Seoul, Korea.
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Education
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Diploma of English, Spanish Official School of Languages at Zaragoza (Escuela Oficial de Idiomas de Zaragoza), Zaragoza, SpainMD, University of Zaragoza, Zaragoza, SpainMPH, University of Minnesota, Minneapolis, MNDrPH, Harvard University, Boston, MA
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Honors and awards
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Six Honor Calls in the MD Program, University of Zaragoza School of Medicine (1981)Fellow of Spain’s Program of Training of Graduate Research of the Ministry of Education and Science, University of Zaragoza (1988)Fulbright Scholar, sponsored by Spain’s Ministry of Health and Consumer Affairs (1989)Faculty Innovation Award, Johns Hopkins University Bloomberg School of Public Health (2001)Scientist Development Award, American Heart Association (2002)Fellow of the American Heart Association, Council on Epidemiology and Prevention (2013)Advising, Mentoring, and Teaching Recognition Award 2014 – 2015, Johns Hopkins University Bloomberg School of Public Health (2015)High Impact Research Icon, University of Malaya (2015)
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Publications
Publications
A Metabolomics Approach To Identify Metabolites Associated with Uremic Symptoms in Patients Receiving Maintenance Hemodialysis
Failed retrieving data.Discontinuation of Beta-Blocker Therapy after Myocardial Infarction
Failed retrieving data.Mitochondrial heteroplasmy is a risk factor for the development of chronic lymphocytic leukemia
Failed retrieving data.Clinical N Staging Subclassification for Stage III-N2 NSCLC Patients Undergoing Trimodality Therapy : A Good Beginning Is Half the Battle
Failed retrieving data.Damage Control in the Wake of Political Action That Threatens the Integrity of Medical Research
Failed retrieving data.Deleterious mitochondrial heteroplasmies exhibit increased longitudinal change in variant allele fraction
Failed retrieving data.Deleterious mitochondrial heteroplasmies exhibit increased longitudinal change in variant allele fraction
Failed retrieving data.Erratum : Long-Term Air Pollution Exposure and Mitochondrial DNA Copy Number: An Analysis of UK Biobank Data (Environ Health Perspect, (2023), 131, 5, 057703, 10.1289/EHP11946)
Failed retrieving data.Framework to prioritize health outcomes of particulate matter exposure using national claims data
Failed retrieving data.Hazardous Environmental Pollutants and Cancer Disparities: A Systematic Review on the Consideration of Race and Ethnicity in Environmental Epidemiology Research
Failed retrieving data.Hearing changes and trajectories during the menopausal transition and their association with metabolic factors
Failed retrieving data.Hearing changes and trajectories during the menopausal transition and their association with metabolic factors
AbstractJang, Y., Chang, Y., Lee, J., Seo, B., Cho, Y., Kim, M., Park, J. H., Kang, J., Kwon, R., Lim, G. y., Kim, K. H., Kim, H., Hong, Y. S., Park, J., Zhao, D., Cho, J., Guallar, E., & Ryu, S. (n.d.).Publication year
2025Journal title
MaturitasVolume
201AbstractBackground: Hearing loss is an emerging public health concern, with women typically experiencing deterioration during menopause; however, longitudinal studies across this transition are limited. This study examined hearing changes across the menopausal transition in order to identify distinct patterns of hearing decline from 11 years before to 9 years after the final menstrual period, with the goal of informing strategies for early detection and intervention. Materials and methods: We followed 4448 women aged 42–52 years who underwent regular health exams at the Kangbuk Samsung Hospital Total Healthcare Centers (2014–2018) through 2023. Hearing changes were analyzed using linear mixed-effects models across the menopausal transition. Group-based trajectory modeling was applied to assess heterogeneity in hearing deterioration relative to the final menstrual period. Results: A significant change in average bilateral hearing thresholds was observed across menopausal transition. Hearing change during the menopausal transition varied by obesity, with minimal change in those with obesity and slight improvement in those without during early transition. Group-based trajectory modeling identified two patterns: Group 1 (71.7 %) had stable hearing until the final menstrual period, then declined; Group 2 (28.3 %) showed poorer baseline hearing with a steeper, persistent decline. At baseline, Group 2 exhibited a significantly higher prevalence of overweight/obesity and hyperglycemia than Group 1. Conclusions: Postmenopausal stages were associated with significant hearing decline in middle-aged women. Furthermore, subgroups with metabolically unhealthy profiles exhibited poorer baseline hearing and a steeper decline in hearing, highlighting the need for appropriate screening and management during the menopausal transition.Impact of tumor size by clinical N subclassification and histology in trimodality-treated N2 non-small cell lung cancer
Failed retrieving data.Impact of tumor size by clinical N subclassification and histology in trimodality-treated N2 non-small cell lung cancer
Failed retrieving data.Introducing Annals Guide to Journal Club : The Importance of Interpreting Clinical Research With Scientific Nuance
AbstractWee, C. C., Guallar, E., & Laine, C. (n.d.).Publication year
2025Journal title
Annals of internal medicineVolume
178Issue
3Page(s)
445-446Abstract~Longitudinal patterns and group heterogeneity of depressive symptoms during menopausal transition in middle-aged Korean women
AbstractJang, Y., Chang, Y., Park, J., Jeon, S. W. W., Seo, B., Park, J. H. H., Kang, J., Kwon, R., Lim, G.-Y. Y., Kim, K.-H. H., Kim, H., Hong, Y. S. S., Park, J., Zhao, D., Cho, J., Guallar, E., & Ryu, S. (n.d.).Publication year
2025Journal title
Epidemiology and psychiatric sciencesVolume
34Page(s)
e57AbstractWhile depressive symptoms are common during menopausal transition, the relationship between the two remains unclear. Therefore, this study aimed to examine the longitudinal changes in depressive symptoms among middle-aged Korean women and identify those with elevated and worsening symptoms during this period.Menopausal stage transitions and associations with overall and domain-specific perceived stress in middle-aged Korean women
Failed retrieving data.Menopausal stage transitions and associations with overall and domain-specific perceived stress in middle-aged Korean women
AbstractJang, Y., Chang, Y., Jeon, S. W., Park, J., Seo, B., Kang, J., Kwon, R., Lim, G. y., Kim, K. H., Kim, H., Hong, Y. S., Park, J., Zhao, D., Cho, J., Guallar, E., & Ryu, S. (n.d.).Publication year
2025Journal title
MaturitasVolume
200AbstractBackground: The menopausal transition, closely linked to later-life health, involves substantial physiological and psychological changes, potentially increasing perceived stress. However, longitudinal studies have reported inconsistent results, with limited data for Asian women, despite the potential for perceived stress to vary with both race and socioeconomic status. Therefore, this study investigated the longitudinal association between menopausal transition and perceived stress among middle-aged Korean women. Materials and methods: We conducted a longitudinal study on 4619 women aged 42–52 who provided written consent in person at the Kangbuk Samsung Hospital Total Healthcare Center between 2014 and 2018. Participants were followed until August 2023, with a median follow-up of 6.6 years (interquartile range: 5.1–7.7), with 2 to 8 repeated comprehensive health screenings. We examined associations between menopausal transition and total scores and domain sub-scores (anger, tension, and depression) on the Perceived Stress Inventory using a linear mixed-effects model. Results: Overall Perceived Stress Inventory and anger scores significantly increased during the late transition stage compared with the pre-menopause stage; however, they decreased during post-menopause. Tension scores showed a similar trend, although the results were not significant. Depression scores significantly increased during the early transition, late transition, and post-menopause stages compared with the pre-menopause stage. Conclusion: Middle-aged Korean women's perceived stress significantly increased during the menopausal transition independent of age, marital status, education, and other confounders. Further research is needed to explore the implications of heightened stress and to assess the potential benefits of targeted interventions for women's health during this period.Menopausal stage transitions and their associations with overall and individual sleep quality in middle-aged Korean women
AbstractJang, Y., Chang, Y., Park, J., Kim, C., Jeon, S. W., Kang, J., Kwon, R., Lim, G. y., Kim, K. H., Kim, H., Hong, Y. S., Park, J., Zhao, D., Cho, J., Guallar, E., Park, H. Y., & Ryu, S. (n.d.).Publication year
2025Journal title
Journal of Affective DisordersVolume
368Page(s)
82-89AbstractBackground: Understanding the association between the menopausal transition and declining sleep quality can guide optimal timing for preventive interventions in transitioning women. However, studies lack representation of Asian women and sufficient data on the progression of menopausal stages and sleep quality changes over time in this population. Methods: This study included 3305 women in the pre-menopause stage at baseline. The sleep quality and its components were assessed using the Pittsburgh Sleep Quality Index (PSQI). Menopausal stages were classified as pre-menopause, early transition, late transition, and post-menopause according to the Stages of Reproductive Aging Workshop+10 (STRAW+10) criteria. We estimated the longitudinal association between menopausal stage changes over time and the PSQI score, and examined the effect of being overweight. Results: The trends in the PSQI scores and its components according to the menopausal stage changes over time showed that with the exception of sleep duration and habitual sleep efficiency, an overall decline was noted in sleep health during late transition and post-menopause compared to pre-menopause. These associations were independent of time-variant annual chronological aging, which was not significantly associated with sleep deterioration. Additionally, although the associations between menopausal stages and sleep quality did not significantly differ by adiposity level, the overweight group exhibited worse PSQI scores and components than did the non-overweight group. Limitation: Sleep quality and menopausal stage were assessed using self-reported questionnaires without objective measures. Conclusion: Our study underscores the importance of screening for sleep quality deterioration and implementing appropriate measures for women experiencing menopausal transition.Reporting guideline for Chatbot Health Advice studies: the CHART statement
Failed retrieving data.Reporting Guideline for Chatbot Health Advice Studies: The CHART Statement
Failed retrieving data.Reporting guideline for chatbot health advice studies: The CHART statement
Failed retrieving data.Response by Zhao et al to Letters Regarding Article, "intracranial Atherosclerotic Disease and Incident Dementia : The ARIC Study (Atherosclerosis Risk in Communities)"
AbstractZhao, D., Guallar, E., & Wasserman, B. A. (n.d.).Publication year
2025Journal title
CirculationVolume
151Issue
12Page(s)
e766Abstract~Safety and efficacy of antiplatelet therapy in patients with intermediate coronary artery stenosis and deferred revascularization
AbstractHong, D., Lee, S. H., Heo, J., Shin, D., Cho, J., Guallar, E., Joh, H. S., Kim, H. K., Ha, J., Choi, K. H., Park, T. K., Yang, J. H., Song, Y. B., Hahn, J. Y., Choi, S. H., Gwon, H. C., Kang, D., & Lee, J. M. (n.d.).Publication year
2025Journal title
Revista Espanola de CardiologiaAbstractIntroduction and objectives: This study investigated the safety and efficacy of antiplatelet therapy in patients with intermediate coronary artery stenosis who underwent deferred revascularization due to their fractional flow reserve (FFR). Methods: A nationwide cohort study was conducted using the Korean National Health Insurance Service database. A total of 4657 patients with intermediate coronary artery stenosis who underwent deferred revascularization due to their FFR were identified from 2013 to 2020. FFR was indicated in patients with no prior evidence of myocardial ischemia and intermediate coronary artery stenosis (50%-70%) as determined by quantitative coronary angiography. Patients were classified according to whether antiplatelet therapy was initiated after the index procedure. The primary efficacy outcome was major adverse cardiac and cerebrovascular events (MACCE), a composite of all-cause death, myocardial infarction, unplanned revascularization, and stroke, during a 5-year follow-up period. The primary safety outcome was any gastrointestinal bleeding. Results: After propensity score matching, there were 1634 patients in the antiplatelet therapy group and 1634 in the nonantiplatelet therapy group. The risk of MACCE was similar between the 2 groups (24.8% vs 24.7%; adjusted HR, 0.97; 95%CI, 0.84-1.13; P = 0.745). The risk of gastrointestinal bleeding was higher in the antiplatelet therapy group than in the nonantiplatelet therapy group (2.2% vs 1.2%; aHR, 2.07; 95%CI, 1.08-4.00). These results were similar in subgroup analyses. Conclusions: In patients with intermediate coronary artery stenosis who underwent deferred revascularization due to their FFR, antiplatelet therapy may increase the risk of gastrointestinal bleeding without reducing the risk of future ischemic events.Scalp cooling for preventing persistent chemotherapy-induced alopecia in anthracycline-treated patients : A single-arm trial
AbstractKang, D., Lee, H., Zhao, D., Kim, N., Kim, H., Kim, S., Kim, J. Y., Park, Y. H., Ahn, H. K., Guallar, E., Cho, J., & Ahn, J. S. (n.d.).Publication year
2025Journal title
Journal of the American Academy of DermatologyAbstract~